BRAF Mutation Test Kit

BRAF, a serine-threonine kinase, is, like KRAS, part of the Ras-Raf-MEK-ERK signalling pathway. BRAF activating mutations are present in melanomas, papillary thyroid cancers, testicular, ovarian and colorectal cancers.

Most common of BRAF activating somatic mutations is V600E mutation. Tumors with this mutation exhibit poor response to anti-EGFR therapy but may be sensitive to selctive inhibitors of BRAF.

BRAF-MMD-PCR Mutation Test Kit enables detection of V600E mutation in b-raf gene against a background of wild-type genomic DNA.