ABL Mutation Test Kit

Chronic myelogenous leukaemia (CML) is a type of myeloproliferative disease characterized by the specific chromosomal translocation (so called Philadelphia chromosome), resulting in the fusion between the Abelson (Abl) tyrosine kinase gene on chromosome 9 and the break point cluster (Bcr) gene on chromosome 22. This fusion produces the BCR-ABL1 oncogene expressing constitutively active tyrosine kinase. CMLs are usually sensitive to treatment with tyrosine kinase inhibitors but in the course of treatment may develop resistance due to the secondary T315I point mutation in Abl kinase domain. Detection of T315I mutation can help in managing those patients who are not responding to current front-line CML therapies.

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ABL-MMD-PCR Mutation Test Kit enables detection of T315I mutation in ABL gene against a background of wild-type genomic DNA.

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Culham Science Centre, Oxfordshire, UK.  OX14 3DB

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