JAK2 Mutation Test Kit

JAK2 is a member of the family of non-receptor tyrosine kinases and is a component of the JAK-STAT signal transduction pathway which regulates cell proliferation, differentiation, apoptosis and function of immune system.

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JAK2 activating mutation, V617F, is implicated in many myeloproliferative disorders (MPD) like polycythemia vera and essential thrombocythopenia and serves as the diagnostic indicator of MPD. Presence of V617F mutation can be used as an indicator for JAK2 inhibitor therapy.

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JAK2-MMD-PCR Mutation Test Kit enables detection of V617F mutation in jak2 gene against a background of wild-type genomic DNA.