Polymerase Chain Displacement Reaction

At least 10-fold increased sensitivity than conventional PCR because PCDR produces twice as much material in each round of thermo-cycling:

 

  • Traditional PCR uses a pair of primers that generate no more than two-fold amplification per cycle

  • For some viruses with frequent mutations a single pair of primers will not be sufficient to identify all variants

  • PCDR uses more than one pair of primers and generates up to four- fold amplification per cycle, giving benefits of:

    • sensitivity higher than PCR

    • speed is improved over PCR

    • all variants are identified

  • PCDR uses conventional PCR platforms

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